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Novel multicomponent reaction for the combinatorial synthesis of 2-imidazolines |
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| Authors: | Bon Robin S Hong Chongen Bouma Marinus J Schmitz Rob F de Kanter Frans J J Lutz Martin Spek Anthony L Orru Romano V A |
| Affiliation: | Department of Chemistry, Vrije Universtiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands. |
| Abstract: | [reaction: see text] The three-component condensation between an amine, an aldehyde, and an alpha-acidic isocyanide efficiently provides substituted 2-imidazolines in a one-pot reaction under mild conditions. |
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