Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites |
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| Authors: | Albada H Bauke Soulimani Fouad Jacobs Hans J F Versluis Cees Weckhuysen Bert M Liskamp Rob M J |
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| Institution: | Utrecht Institute for Pharmaceutical Sciences, Medicinal Chemistry & Chemical Biology, Faculty of Science, University of Utrecht, Utrecht, The Netherlands. |
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| Abstract: | We describe the synthesis and coordination behaviour to copper(II) of two close structural triazacyclophane-based mimics of two often encountered aspartic acid and histidine containing metalloenzyme active sites. Coordination of these mimics to copper(I) and their reaction with molecular oxygen leads to the formation of dimeric bis(μ-hydroxo) dicopper(II) complexes. |
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