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Stereoselective synthesis of N-aryl proline amides by biotransformation-Ugi-Smiles sequence |
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| Authors: | Znabet Anass Blanken Sara Janssen Elwin de Kanter Frans J J Helliwell Madeleine Turner Nicholas J Ruijter Eelco Orru Romano V A |
| Affiliation: | Department of Chemistry & Pharmaceutical Sciences and Amsterdam Institute of Molecules, Medicines and Systems, VU University Amsterdam, Amsterdam, The Netherlands. |
| Abstract: | An efficient combination of MAO-N-catalyzed desymmetrization of cyclic meso-amines with Ugi-Smiles multicomponent chemistry produced optically pure N-aryl proline amides. This method represents the first report of a fully asymmetric Ugi-Smiles process. |
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