1H and 13C NMR studies of the protonation of isomeric methoxysulmazole analogues |
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| Authors: | J. C. Lindon J. M. Williams P. Barraclough W. R. King M. S. Nobbs |
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| Affiliation: | 1. Department of Physical Sciences, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, UK;2. Department of Medicinal Chemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, UK |
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| Abstract: | ![]()
The major protonation sites of six cardiotonic isomeric 2-aryl-n-methoxy-1H-imidazo[4,5-b]- and -[4,5-c]-pyridines (n = 4–7) were determined by 1H and 13C NMR methods. All the 1H-imidazo[4,5-c]pyridines and the 7-methoxy derivative of sulmazole were found to protonate at the pyridyl nitrogen. Protonation occurred at the imidazo nitrogen, however, for the 5- and 6-methoxy derivatives of sulmazole. |
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| Keywords: | Inotropism Imidazopyridine 13C NMR 1H NMR Tautomerism |
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