1H and 13C assignments of two new macrocyclic lactones isolated from Streptomyces sp. 211726 and revised assignments of azalomycins F3a, F4a and F5a |
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| Authors: | Yuan Ganjun Lin Haipeng Wang Cheng Hong Kui Liu Yue Li Jia |
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| Institution: | 1. Key Laboratory of Tropical Microbial Resources, Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China;2. Department of Pharmacy, Hainan Medical College, Haikou 571101, China;3. Agriculture College, Hainan University, Haikou 570228, China;4. National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | Azalomycin F(4a) 2-ethylpentyl ester (1) and Azalomycin F(5a) 2-ethylpentyl ester (2), two new macrocyclic lactones, along with three known compounds of Azalomycins F(3a) (3), F(4a) (4) and F(5a) (5), were identified from metabolites of Streptomyces sp. 211726 isolated from mangrove rhizosphere soil. The complete (1)H and (13)C assignments of these compounds were achieved by using (1)H, (13)C, DEPT, HSQC, (1)H-(1)H COSY and HMBC spectra, and the relative stereochemistry of 5 was first elucidated on the basis of proton-proton coupling constants, NOESY and IR spectra. Moreover, some errors in the (1)H and (13)C assignments published of 3, 4 and 5 were found and revised. 1 and 2 were active against Candida albicans, and exhibited moderate cytotoxicity against HCT-116 cell line. |
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| Keywords: | NMR 1H NMR 13C NMR 2D NMR Azalomycin F4a 2‐ethylpentyl ester Azalomycin F5a 2‐ethylpentyl ester Streptomyces sp 211726 macrocyclic lactone |
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