Novel cytotoxic icetexane diterpenes from Premna latifolia Roxb |
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| Authors: | G SureshK Suresh Babu V Rama Subba RaoM Suri Appa Rao V Lakshma NayakSistla Ramakrishna |
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| Institution: | a Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500607, India
b Pharmacology Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500607, India |
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| Abstract: | Chromatographic fractionation of a hexane extract from stem-bark of Premna latifolia yielded three new icetexane diterpenes (1-3). Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS, data. Compounds 1-3 were also evaluated for the cytotoxicity against the cancer cell lines (HT-29, A-431, MCF-7, Hep-G2, PC-3, A-549, B-16 F10 and ACHN). Compounds 1 and 2 displayed potent cytotoxic activity against HT-29 and Hep-G2 cell lines with IC50 values of 0.04 and 0.18 μg/mL, respectively. |
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| Keywords: | Premna latifolia Icetexane diterpenes Cytotoxic activity Cancer cell lines |
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