| N-取代芳酰氨基-5-氟代苯基-2-呋喃甲酰硫脲的合成与生物活性测定 |
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| 引用本文： | 薛思佳,卞王东,柴安,吁松瑞. N-取代芳酰氨基-5-氟代苯基-2-呋喃甲酰硫脲的合成与生物活性测定[J]. 有机化学, 2008, 28(5): 865-869 |
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| 作者姓名： | 薛思佳 卞王东 柴安 吁松瑞 |
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| 作者单位： | 上海师范大学生命与环境科学学院化学系,上海,200234 |
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| 基金项目： | 国家自然科学基金，上海市重点学科建设项目 |
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| 摘 要： | 从5-氟代苯基-2-呋喃甲酸出发, 经酰化、异硫氰酸酯化, 再与取代芳酰肼反应合成了20个未见文献报道的N-取代芳酰氨基-5-氟代苯基-2-呋喃甲酰硫脲. 目标产物的结构经IR, 1H NMR和元素分析测定确证. 初步生物活性测试表明, 部分化合物对棉花枯萎病、黄瓜灰霉病、苹果轮纹病和棉花炭疽病有较好的选择性杀菌活性; 部分目标化合物有较好的除草活性.
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| 关 键 词： | 取代芳酰肼 5-氟代苯基-2-呋喃甲酰硫脲 合成 生物活性 |
| 收稿时间： | 2007-10-09 |
| 修稿时间： | 2007-10-10 |
Synthesis and Biological Activities of N-(Substitutedaroylamino)-5-(fluorophenyl)-2-furoyl Thioureas |
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| XUE,Si-Jia,BIAN,Wang-Dong,CHAI,An,YU,Song-Rui. Synthesis and Biological Activities of N-(Substitutedaroylamino)-5-(fluorophenyl)-2-furoyl Thioureas[J]. Chinese Journal of Organic Chemistry, 2008, 28(5): 865-869 |
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| Authors: | XUE Si-Jia BIAN Wang-Dong CHAI An YU Song-Rui |
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| Affiliation: | (College of Life and Environment Science, Shanghai Normal University, Shanghai 200234) |
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| Abstract: | Twenty new N-(substituted aroylamino)-5-(fluorophenyl)-2-furoyl thioureas were synthesized and their structures were determined by 1H NMR, IR spectra and elemental analysis. The preliminary biological activity tests show that some of these target compounds have good fungicidal activities and some have good herbicidal activities. |
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| Keywords: | hydrazide 5-(fluorophenyl)-2-furoyl thiourea synthesis biological activity |
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