以G-四链体为靶点的小分子端粒酶抑制剂研究进展

富含鸟嘌呤碱基的DNA序列能够通过鸟嘌呤环的互联作用形成四链螺旋结构，这种结构被称为G-四链体。G-四链体由于能够抑制端粒酶的活性而成为抗肿瘤药物的新靶点，能促使G-四链体形成或稳定该结构的物质则可能对癌症有潜在的治疗意义。本文对以G-四链体为靶点的小分子端粒酶抑制剂的研究进行了综述。

Progress in the Study of G-quadruplex-targeted Telomerase Inhibitors

In addition to the familiar duplex DNA, certain G-rich DNA sequences can fold into a variety of four-stranded structures, which are called G-quadruplexes. Considerable circumstantial evidence suggests that telomerase activity can be directly inhibited by formation of G-quadruplex structures. The substances that can promote the formation and stabilize the G-quadruplex structures have potential uses for the cure of cancer. Current developments in G-quadruplex-targeted telomerase inhibitors as anti-cancer drugs are reviewed in this article.