A high voltage asymmetric waveform generator for FAIMS |
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Authors: | Jesse D Canterbury James Gladden Lon Buck Roy Olund Michael J MacCoss |
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Institution: | 1.Department of Genome Sciences,University of Washington,Seattle,USA;2.Department of Chemistry,University of Washington,Seattle,USA |
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Abstract: | High field asymmetric waveform ion mobility spectrometry (FAIMS) has been used increasingly in recent years as an additional
method of ion separation and selection before mass spectrometry. The FAIMS electrodes are relatively simple to design and
fabricate for laboratories wishing to implement their own FAIMS designs. However, construction of the electronics apparatus
needed to produce the required high magnitude asymmetric electric field oscillating at a frequency of several hundred kilohertz
is not trivial. Here we present an entirely custom-built electronics setup capable of supplying the required waveforms and
voltages. The apparatus is relatively simple and inexpensive to implement. We also present data acquired on this system demonstrating
the use of FAIMS as a gas-phase ion filter interface to an ion trap mass spectrometer. |
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