高脂饲料对长爪沙鼠血脂和血清电解质的影响

目的观察高脂饲料对长爪沙鼠血清脂质4项和血清电解质K^＋、Na^＋、Cl^-、Ca^2＋、Mg^2＋含量的影响。方法选取雄性长爪沙鼠40只,随机分为两组,分别给予普通饲料和高脂饲料（含1%胆固醇、10%猪油）。喂养12周后颌下静脉丛采血,用日立7180型全自动生化分析仪检测血清TC、TG、HDL-C、LDL-C及Ca^2＋、Mg^2＋含量,用美国Easy Lyte Plus型电解质分析仪检测血清K^＋、Na^＋、Cl^-含量。结果与正常饲料组相比,高脂饲料喂养后沙鼠血清TC、TG、HDL-C、LDL-C含量显著升高（P〈0.01）,以TC、LDL-C水平升高最为明显。沙鼠血清电解质K^＋、Mg^2＋含量在不同饲料组差异有显著性（P〈0.01或P〈0.05）,而Na^＋、Cl^-、Ca^2＋含量在不同饲料喂养组的差异不显著（P〉0.05）。结论高脂饲料能明显升高长爪沙鼠血清脂质4项,并改变其血清电解质K^＋、Mg^2＋水平。

The Effect of High-fat Diet on Serum Lipid Parameters and Electrolyte Values in Mongolian Gerbils

Objective To observe the effect of a high-fat diet on serum lipid parameters and electrolyte values of K^＋,Na^＋,Cl^-,Ca^2＋,Mg^2＋ in Mongolian gerbils. Methods Forty male Mongolian gerbils were selected and divided randomly into two groups（ 20 each group）. The first group of Mongolian gerbils were fed with a normal animal feed,while the second group were given a high-fat diet enriched with 1% cholesterol and 10% lard for twelve weeks. The serum samples were collected and tested for total cholesterol（ TC）,triglycerides（ TG）,high density lipoprotein cholesterol（ HDL-C）,low density lipoprotein cholesterol（ LDL-C）,and Ca^2＋,Mg^2＋ values using Hitachi 7180 auto-analyser,and for serum values of K^＋、Na^＋、Cl^- using Easy Lyte Plus electrolyte analyzer. Results Compared with normal animal feed group,the dietary intake of enriched with 1% cholesterol and 10% lard significantly increased the level of TC,TG,HLDL-C and LDL-C in the serum of Mongolian gerbils（ P〈0. 01）,and the serum level of TC and LDL-C were elevated remarkably. Meanwhile,the serum electrolyte K＋and Mg^2＋ values were also significantly increased（ P〈0. 01 and P〈0. 05）,while there were no significant difference in electrolyte Na^＋、 Cl^-、 Ca^2＋ values between both gerbils（ P〈0. 05）.Conclusion High-fat diet could significantly promote serum lipid parameters,and improve serum electrolyte K^＋、Mg^2＋ values in Mongolian gerbils.