Microwave-assisted and scandium triflate catalyzed synthesis of tetrahydrobenzo[<Emphasis Type="Italic">a</Emphasis>]xanthen-11-ones |
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| Authors: | Madharam Sudershan Rao Bhupender S Chhikara Rakesh Tiwari Amir N Shirazi Keykavous Parang Anil Kumar |
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| Institution: | (1) Department of Chemistry, Birla Institute of Technology and Science, Pilani, 333031, India;(2) Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA; |
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| Abstract: | Abstract Synthesis of 12-aryl-8,9,10,12-tetrahydro-benzoa]xanthen-11-ones was achieved by one-pot condensation of β-naphthol, substituted benzaldehydes, and 1,3-dicarbonyl compounds
catalyzed by Sc(OTf)3 under microwave irradiation in excellent isolated yields. The catalyst was recycled up to four cycles with no appreciable
loss in catalytic activity. The compounds were evaluated for Src kinase activity and anticancer activity. |
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