Succinimide sulfonic acid (SuSA): an efficient and recyclable catalyst for the chemoselective <Emphasis Type="Italic">N</Emphasis>-Boc protection of amines |
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Authors: | Farhad Shirini Nader Ghaffari Khaligh |
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Institution: | (1) Department of Chemistry, College of Science, University of Guilan, 41335 Rasht, Iran |
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Abstract: | Abstract Succinimide sulfonic acid (SuSA) as a stable reagent is easily prepared by the reaction of succinimide with neat chlorosulfonic
acid. This compound is able to catalyze the chemoselective conversion of amines to their corresponding N-Boc protected derivatives with (Boc)2O. All reactions were performed under mild conditions, giving the desired products in good to high yields. |
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