| 1-(取代吡唑-4-甲酰基)吡唑类化合物的合成及生物活性研究 |
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| 引用本文： | 程永浩,邹小毛,高颖,杨华铮.1-(取代吡唑-4-甲酰基)吡唑类化合物的合成及生物活性研究[J].高等学校化学学报,2004,25(11):2024-2027. |
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| 作者姓名： | 程永浩 邹小毛 高颖 杨华铮 |
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| 作者单位： | 南开大学元素有机化学研究所, 元素有机化学国家重点实验室, 天津300071 |
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| 基金项目： | 国家自然科学基金 (批准号 :2 0 172 0 3 1)，教育部博士学科点专项基金资助 |
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| 摘 要： | 设计合成了25个新型1-取代吡唑甲酰基吡唑系列衍生物,化合物结构经1HNMR、元素分析、IR和MS确证.生物活性测试结果表明,该类化合物具有一定除草活性,讨论了其结构与活性的关系.
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| 关 键 词： | HPPD抑制剂 合成 吡唑 生物活性 构效关系 |
| 文章编号： | 0251-0790(2004)11-2024-04 |
| 收稿时间： | 2003-10-07 |
Synthesis and Biological Activity of Novel 1-(Substituted-pyrazole-4-carbonyl) Pyrazoles |
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| CHENG Yong-Hao,ZOU Xiao-Mao,GAO Ying,YANG Hua-Zheng.Synthesis and Biological Activity of Novel 1-(Substituted-pyrazole-4-carbonyl) Pyrazoles[J].Chemical Research In Chinese Universities,2004,25(11):2024-2027. |
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| Authors: | CHENG Yong-Hao ZOU Xiao-Mao GAO Ying YANG Hua-Zheng |
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| Institution: | State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | A series of new 1-(substituted-pyrazole-4-carbonyl)-pyrazoles were synthesized by the reaction of 5-amino-1-methyl-3-(methylthio)-1H-pyrazole-4-carbohydrazide and 5-amino-1-methyl-1H-pyrazole-4-carbohydrazide respectively with 2-cyano-3,3-bis(alkylthio) acrylates or 2-\malononitriles. All the compounds were structurally confirmed by elemental analysis and 1H NMR. Their herbicidal activities were tested. Bioassay results showed that some of them had herbicidal activities. The structure-activity relationship was discussed, which indicated the substituents on the pyrazole ring have influence on the title compounds activities. |
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| Keywords: | HPPD inhibitor Synthesis Pyrazole Biological activity Structure-activity relationship |
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