Aggregation and adhesion of gold nanoparticles in phosphate buffered saline |
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Authors: | Shangfeng Du Kevin Kendall Panteha Toloueinia Yasamin Mehrabadi Gaurav Gupta Jill Newton |
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Institution: | (1) School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK |
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Abstract: | In applications in medicine and more specifically drug delivery, the dispersion stability of nanoparticles plays a significant
role on their final performances. In this study, with the use of two laser technologies, dynamic light scattering (DLS) and
nanoparticle tracking analysis (NTA), we report a simple method to estimate the stability of nanoparticles dispersed in phosphate
buffered saline (PBS). Stability has two features: (1) self-aggregation as the particles tend to stick to each other; (2)
disappearance of particles as they adhere to surrounding substrate surfaces such as glass, metal, or polymer. By investigating
the effects of sonication treatment and surface modification by five types of surfactants, including nonylphenol ethoxylate
(NP9), polyvinyl pyrrolidone (PVP), human serum albumin (HSA), sodium dodecyl sulfate (SDS) and citrate ions on the dispersion
stability, the varying self-aggregation and adhesion of gold nanoparticles dispersed in PBS are demonstrated. The results
showed that PVP effectively prevented aggregation, while HSA exhibited the best performance in avoiding the adhesion of gold
nanoparticle in PBS onto glass and metal. The simple principle of this method makes it a high potential to be applied to other
nanoparticles, including virus particles, used in dispersing and processing. |
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