Oxidation and determination of Gabapentin on nanotubes of nickel oxide-modified carbon paste electrode |
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| Authors: | Hossein Heli F Faramarzi N Sattarahmady |
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| Institution: | (1) Laboratory of Analytical and Physical Electrochemistry, Department of Chemistry, Science and Research Branch, Islamic Azad University, Fars, Iran;(2) Young Researchers Club, Science and Research Branch, Islamic Azad University, Fars, Iran;(3) Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran;(4) Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran |
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| Abstract: | The electrooxidation of Gabapentin was studied on nanotubes of nickel oxide-modified carbon paste electrode for the first time. Cyclic voltammetry was employed
to investigate the electrooxidation process. A simple, sensitive, and efficient amperometric method was developed for the
analysis of the drug, and the corresponding analytical parameters were reported. For Gabapentin, a detection limit of 0.3 μM
was obtained in a linear range of 2.4–50 μM. The proposed amperometric method was also applied to the analysis of commercial
capsules, and the results were in good agreement with the declared values. Also, the applicability of the method to the direct
assay of the drug in human serum and urine was described. |
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