Study of the interfacial polycondensation of isocyanate in the preparation of benzalkonium chloride loaded microcapsules |
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Authors: | A M Pensé C Vauthier J P Benoit |
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Institution: | (1) Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, URA CNRS 1218, Université de Paris XI, Faculté de Pharmacie, 92 296 Chatenay-Malabry Cedex, France;(2) Laboratoire de Pharmacie Galénique, Faculté de Pharmacie, Angers, France |
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Abstract: | The preparation of benzalkonium chloride loaded microcapsules was performed by interfacial polycondensation of isocyanates. The present study was made in order to clarify parameters affecting microcapsule wall formation during the course of polymerization. The results presented here show that many interrelated parameters are involved during the microcapsule formation. Each individual component introduced in the preparation was shown to have an effect either on the morphology of the microcapsules or on the mechanical resistance. Benzalkonium chloride seemed to interact mainly in the interfacial polymer precipitation step through a salt effect, or influence the polycondensation reaction rate acting as a catalyst. A contribution of the hydroxylic functions of the surfactant in the polycondensation reaction of the isocyanate was also highlighted. Finally, the organic phase composition was found to be able to modulate the reactivity of hydroxylic functions of the surfactant, leading to very slow reactions in pure xylene. These effects were related to the characteristics of the microcapsules obtained according to different compositions of the formulation system. |
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Keywords: | Isocyanate benzalkonium chloride interfacial polycondensation microcapsules |
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