Characterisation of the essential oil of Nepeta glomerata Montbret et Aucher ex Bentham from Lebanon and its biological activities |
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Authors: | Rigano Daniela Arnold Nelly Apostolides Conforti Filomena Menichini Federica Formisano Carmen Piozzi Franco Senatore Felice |
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Institution: | Department of Chemistry of Natural Compounds, University of Naples Federico II, via D. Montesano, 49, I-80131 Naples, Italy. |
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Abstract: | The essential oil of Nepeta glomerata from Lebanon was studied by means of GC and GC/MS analysis; 70 compounds were identified. The oil was constituted mainly by monoterpenes and the most abundant components were α-pinene, spathulenol and carvacrol. Nepeta glomerata oil showed antibacterial activity, particularly towards Gram-positive bacteria, and also inhibited LPS-induced NO production in macrophage cell line RAW 264.7, with an IC(50) value of 78.1 μg mL(-1). Furthermore, an in?vitro cytotoxic assay showed that the oil was more active on a renal adenocarcinoma cell line (48% of inhibition of proliferation at 100 μg mL(-1)) in comparison to an amelanotic melanoma. |
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