Reactions of alkyl acetone-1,3-dicarboxylates with cyanamide and benzoylcyanamide

The reactions of cyanamide with dialkyl acetone-1,3-dicarboxylates in the presence of nickel acetylacetonate afforded alkyl 2-amino-4-hydroxy-6-oxo-1,6-dihydropyridine-3-carboxylates. The same compounds were obtained by intramolecular cyclization of adducts of acetone-1,3-dicarboxylates with benzoylcyanamide under the action of sodium alkoxides. Dedicated to Academician N. K. Kochetkov on the occasion of his 90th birthday. __________ Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1304–1306, May, 2005.