Synthesis of omega-(hetero)arylalkynylated alpha-amino acid by Sonogashira-type reactions in aqueous media |
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Authors: | Brea Roberto J López-Deber M Pilar Castedo Luis Granja Juan R |
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Affiliation: | Departamento de Química Organica e Unidade Asociada ó C.S.I.C., Facultade de Química, Universidade de Santiago, 15782 Santiago de Compostela, Spain. |
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Abstract: | Mild conditions are described that allow the palladium-catalyzed cross-coupling of C(alpha)-alkynylated glycine with a wide variety of electron-rich and electron-poor aryl and heteroaryl halides in aqueous media. |
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