Rapid determination of quinolones in cosmetic products by ultra high performance liquid chromatography with tandem mass spectrometry |
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| Authors: | Shao‐Ying Liu Xi‐Hui Huang Xiao‐Fang Wang Quan Jin Guo‐Nian Zhu |
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| Institution: | 1. Laboratory of Chemistry and Physics, Hangzhou Center for Disease Control and Prevention, Hangzhou, P. R. China;2. Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, P. R. China |
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| Abstract: | This study developed an improved analytical method for the simultaneous quantification of 13 quinolones in cosmetics by ultra high performance liquid chromatography combined with ESI triple quadrupole MS/MS under the multiple reaction monitoring mode. The analytes were extracted and purified by using an SPE cartridge. The limits of quantification ranged from 0.03 to 3.02 μg/kg. The precision for determining the quinolones was <19.39%. The proposed method was successfully developed for the determination of quinolones in real cosmetic samples. |
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| Keywords: | Cosmetics Quinolones Tandem mass spectrometry Ultra high performance liquid chromatography |
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