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A study on the sulfenylchlorination of cembrene and the related cembranoids |
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| Authors: | Liu Zhu-Jin Li Yun-Long Chen Qing-Zhi Wang Wei-Qi |
| Abstract: | p-Tolylsulfenyl chloride adds regioselectively at the C(11) ? C(12) bond of cembrene 1 to give 11-(R)-p-tolylthio-1-(S)-cembra-2E, 4Z, 7E, 12(20)-tetraene 2 following a rapid HCl elimination. Two new cembranoids, 1-(S)-cembra-2E, 4Z, 7E, 12(20)-tetraene 3 and 1-(S)-cembra-2E, 4Z, 7E, 11Z-tetraen-20-ol 4 are prepared from 2. |
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