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| 硒-甲基硒代半胱氨酸的合成与拆分研究 | |
| 引用本文： | 刘建群,刘芳,张小平,寇晓莉.硒-甲基硒代半胱氨酸的合成与拆分研究[J].化学研究与应用,2008,20(11). |
| 作者姓名： | 刘建群 刘芳 张小平 寇晓莉 |
| 作者单位： | 1. 江西中医学院现代中药制剂教育部重点实验室,江西,南昌,330004 2. 江西萍乡高等专科学校化工系,江西,萍乡,337055 3. 江西川奇药业有限公司,江西,南昌,330029 |
| 基金项目： | 南昌市科技型中小企业技术创新基金 |
| 摘 要： | 天然硒-甲基硒代半胱氨酸为L型含硒氨基酸,是第21种人体必须氨基酸———硒代半胱氨酸的甲基化衍生物。1960年首次由Trelease S·F·等从美国黄芪中分离得到1],它还广泛存在于大蒜、洋葱和椰菜等植物以及富硒酵母中。硒-甲基硒代半胱氨酸具有补硒、防治癌症、抗氧化、抗衰老、 |
| 关 键 词： | 硒-甲基硒代半胱氨酸 2-乙酰氨基丙烯酸 2-乙酰氨基丙烯酸甲酯 合成 拆分 |
Synthesis and resolution of Se-methylselenocysteine |
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| LIU Jian-qun,LIU Fang,ZHANG Xiao-ping,KOU Xiao-li.Synthesis and resolution of Se-methylselenocysteine[J].Chemical Research and Application,2008,20(11). | |
| Authors: | LIU Jian-qun LIU Fang ZHANG Xiao-ping KOU Xiao-li |
| Abstract: | 2-Acetamidoacrylic acid or methyl 2-acetamidoacrylate is reacted with solution of sodium of methylselenol to give N-acetyl-Se-methylselenocysteine.The L(and D)-Se-methylselenocysteine have been prepared in high optical purity by treating N-acetyl-Se-methylselenocysteine in water using acylase I from porcine kidney as a catalyst.The influencing factors on the resolution reaction are discussed by orthogonal experiment,including pH value,reaction temperature,concentration of Co2 and amount of acylase I.Under the optimizing resolution conditions,L(and D)-Se-methylselenocysteine are obtained with>96 % optical purity in about 40% yield. |
| Keywords: | Se-methylselenocysteine 2-acetamidoacrylic acid methyl 2-acetamidoacrylate synthesis resolution |
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