Synthesis of new 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-ones under catalyst-free and solvent-free conditions

Several new 1,5-diaryl-3-(arylamino)-1H-pyrrol-2(5H)-ones were synthesized via the three-component condensation reaction of aldehydes, aromatic amines, and ethyl pyruvate under catalyst-free and solvent-free conditions. Also, 5-(4-hydroxyl-3-nitrophenyl)-1-(4-methoxy-phenyl)-3-(4-methoxyphenylamino)-1,5-dihydro-pyrrol-2-one was synthesized using oxime instead of aldehyde. The eco-friendly, simple procedure, green procedure, catalyst-free and solvent-free conditions, short reaction times, and high yields of the products are the advantages of this method.