Molecular design and biological potential of galacto-type trehalose as a nonnatural ligand of shiga toxins |
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| Authors: | Dohi Hirofumi Nishida Yoshihiro Furuta Yuki Uzawa Hirotaka Yokoyama Shin-ichiro Ito Saori Mori Hiroshi Kobayashi Kazukiyo |
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| Institution: | Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan. |
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| Abstract: | Galacto-type trehalose, a "C-4 epimer of trehalose", possesses a stereochemical structure around the alpha(1-1)-linkage analogous to that of the globobiosyl alpha(1-4)-linkage in Gb(2) and Gb(3) ceramides, which are known as the ligands of Shiga toxins produced by pathogenic E. coli. This paper presents evidence supporting the new idea of using a trehalosyl alpha(1-1)-linkage as a substitute for the galactobiosyl alpha(1-4)-linkage. |
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