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First total synthesis of (±)-adunctin B |
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| Authors: | Kenji ArimitsuSayo Nomura Hiroki IwasakiMinoru Ozeki Masayuki Yamashita |
| Affiliation: | Kyoto Pharmaceutical University, 5 Misasagi-Nakauchi, Yamashina, Kyoto 607-8414, Japan |
| Abstract: | The first total synthesis of (±)-adunctin B (1), a natural product isolated from Piper aduncum (Piperaceae) and having antibacterial activity, was achieved in 1.26% overall yield in 15 steps from 5,7-dimethoxycoumarin-3-carboxylate (8). |
| Keywords: | Adunctin B Total synthesis Ylide Skeleton transformation Stereoselective alkylation |
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