An Iridium Complex as an AIE-active Photosensitizer for Image-guided Photodynamic Therapy |
| |
| Authors: | Ke Yang Yi Zhou Yaping Wang Dr Shaojing Zhao Xiaoli Wu Dr Xiao Peng Li Huang Lirong Jiang Prof Minhuan Lan Prof Xiao-Yi Yi |
| |
| Institution: | 1. Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083 P. R. China;2. College of Light Industry and Food Engineering, Guangxi University, Nanning, 530004 P. R. China;3. Center of Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems, Shenzhen University, Shenzhen, 518060 P. R. China |
| |
| Abstract: | Image-guided photodynamic therapy (PDT) has received growing attention due to its non-invasiveness and precise controllability. However, the PDT efficiency of most photosensitizers are decreased in living system due to the aggregation-caused singlet oxygen (1O2) generation decreasing. Herein, we present an Iridium (III) pyridylpyrrole complex (Ir-1) featuring of aggregation-induced emission (AIE) and 1O2 generation characteristics for image-guided PDT of cancer. Ir-1 aqueous solution exhibits bright red phosphorescence peaked at 630 nm, large Stokes shift of 227 nm, and good 1O2 generation ability. The 1O2 generating rate of Ir-1 in EtOH/water mixture solution is 2.3 times higher than that of Rose Bengal. In vitro experimental results revealed that Ir-1 has better biocompatibility and higher phototoxicity compared with clinically used photosensitizers (Rose Bengal and Ce6), suggesting that Ir-1 can serve as a photosensitizer for image-guided PDT of cancer. |
| |
| Keywords: | photodynamic therapy iridium (III) pyridylpyrrole complex aggregation-induced emission |
|
|
