Synthesis and Crystal Structure of Tetramethyl 4aH-Pyrido [1, 2-a] Quinoline-1,2,3,4-Tetracarboxylate

1 INTRODUCTION Alkaloids and their derivatives are ubiquitous in natural products, and most of those compounds are of biological activities. Therefore, the structure modifi- cation of alkaloids is always the point that organic chemists and medicinal chemists focus on1~10]. Qui- nolizine ring system is an important kind of alkaloid, which has a nitrogen atom shared by two six-mem- bered rings. Many medicines have quinolizine ring system, such as reserpine11, 12] and berberine13]. How- …

Synthesis and Crystal Structure of Tetramethyl 4aH-Pyrido [1, 2-a] Quinoline-1,2,3,4-Tetracarboxylate

The crystal structure of the title compound with good acetylcholinesterase inhi- bitory activity (C21H19NO8, Mr = 413.37) has been determined by single-crystal X-ray diffraction analysis. The crystal is of monoclinic, space group P21 with a = 10.257(3), b = 8.954(3), c = 11.541(4)(A), β = 109.772(6)o, V = 997.5(6)(A)3, Dc = 1.376 g/cm3, μ = 0.107 mm-1, Z = 2, F(000) = 432, S = 1.041, the final R = 0.0356 and wR = 0.0884. In the molecular structure, the ring of N(1)-C(5)-C(6)-C(7)-C(8)-C(13) is of twisting-boat conformation, and the ring of N(1)-C(1)- C(2)-C(3)-C(4)-C(5) is nearly a plane.