Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins |
| |
| Authors: | Dr Xi Zhu Dr Jun Wu Wei Shan Dr Wei Tao Dr Lili Zhao Dr Jong‐Min Lim Mathew D'Ortenzio Prof Rohit Karnik Prof Yuan Huang Prof Jinjun Shi Prof Omid C Farokhzad |
| |
| Institution: | 1. Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China;2. Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA;3. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA;4. King Abdulaziz University, Jeddah, Saudi Arabia |
| |
| Abstract: | Effective delivery of therapeutic proteins is a formidable challenge. Herein, using a unique polymer family with a wide‐ranging set of cationic and hydrophobic features, we developed a novel nanoparticle (NP) platform capable of installing protein ligands on the particle surface and simultaneously carrying therapeutic proteins inside by a self‐assembly procedure. The loaded therapeutic proteins (e.g., insulin) within the NPs exhibited sustained and tunable release, while the surface‐coated protein ligands (e.g., transferrin) were demonstrated to alter the NP cellular behaviors. In vivo results revealed that the transferrin‐coated NPs can effectively be transported across the intestinal epithelium for oral insulin delivery, leading to a notable hypoglycemic response. |
| |
| Keywords: | drug delivery insulin nanoparticles polymers transcytosis |
|
|
