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N‐Heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones |
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| Authors: | Dr. Changgui Zhao Fangyi Li Prof. Dr. Jian Wang |
| Affiliation: | 1. Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, China;2. Tsinghua–Peking Centre for Life Sciences, Beijing, China |
| Abstract: | The dynamic kinetic resolution of 6‐hydroxypyranones with enals or alkynals through an asymmetric redox esterification is catalyzed by a chiral N‐heterocyclic carbene. The resulting esters are obtained in good to high yields and with high levels of enantio‐ and diastereocontrol. The reaction products are further derivatized to obtain functionalized sugar derivatives and natural products. |
| Keywords: | catalysis dynamic kinetic resolution glycosylation N-heterocyclic carbenes pyranones |