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Total Synthesis of (+)‐MPC1001B |
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| Authors: | Taichi Kurogi Shun Okaya Dr. Hideto Fujiwara Dr. Kentaro Okano Prof. Dr. Hidetoshi Tokuyama |
| Affiliation: | Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba 6‐3, Aramaki, Aoba‐ku, Sendai 980‐8578 (Japan) |
| Abstract: | The first total synthesis of an epidithiodiketopiperazine alkaloid, (+)‐MPC1001B, was accomplished. This synthesis features a tetra‐n‐butylammonium fluoride mediated intramolecular aldol reaction for forming the 15‐membered macrolactone ring, and the construction of an epidithiodiketopiperazine substructure through a stepwise sulfenylation reaction involving a novel trityl trisulfide (TrSSS)‐group transfer. |
| Keywords: | aldol reaction alkaloids dithiodiketopiperazine macrolactones total synthesis |