Visible‐Light‐Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide |
| |
| Authors: | Qing‐Yu Lin Dr. Xiu‐Hua Xu Ke Zhang Prof. Dr. Feng‐Ling Qing |
| |
| Affiliation: | 1. KeyLaboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, China;2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China |
| |
| Abstract: | ![]()
Bromodifluoromethylphosphonium bromide was solely used as the precursor of difluorocarbene. Herein, an unprecedented visible‐light‐induced hydrodifluoromethylation of alkenes with bromodifluoromethylphosphonium bromide using H2O and THF as hydrogen sources for the synthesis of difluoromethylated alkanes is described. This difluoromethylation is characterized by mild reaction conditions, ready availability of reagents, and excellent functional‐group tolerance. |
| |
| Keywords: | alkenes fluorine photoredox catalysis radicals synthetic methods |
|
|
