微流控芯片高通量试样引入系统的研究

基于微流控芯片试样引入技术的研究是目前微流控芯片分析领域内的重要研究方向之一，其目的是实现宏观外部系统(进行10^-6～1L级液体的操作)与芯片系统(进行10^-12～10^-9 L级液体的操作)的衔接(world-to-chip interfacing)．目前文献报道的微流控分析系统，包括芯片流动注射系统，

High Throughput Sample Introduction System for Microfluidic Chips

A high-throughput sample introduction system for chip-based microfluidic analysis was developed. The sampling system was composed of a capillary sampling probe attached to the microchip channel and an array of horizontally positioned micro-sample vials with slits fabricated on the bottom of each vial for pass-through of the sampling probe. The micro-sample vials array was fixed on a homebuilt platform capable of moving linearly under computer control. Sample introduction was performed by linearly moving the array of vials,allowing the probe inlet to sequentially enter the solutions in the vials through the slits. The use of a slotted vial array in the sample introduction system allowed convenient and rapid sample change with low sample volume in 10\+\{-9\} L range and high sampling frequency without requiring mechanical valves and pumps. The system was applied to achieve continuously automated sample change in a chip-based flow injection analysis system with absorption detection by using a liquid-core waveguide capillary flow-cell. High sampling throughput of 600 h -1 was obtained in this system with a sample consumption of only 4.3 nL for each cycle.