Free-breathing radial volumetric interpolated breath-hold examination sequence and dynamic contrast-enhanced MRI combined with diffusion-weighted imaging for assessment of solitary pulmonary nodules |
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| Affiliation: | 1. Department of Radiation Oncology, The University of Colorado Hospital, Aurora, CO;2. Department of Urology, The University of Colorado Hospital, Aurora, CO;3. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX;4. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX;1. Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, Italy;2. Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, United States;3. Department of Radiological Sciences, University of California, Los Angeles, CA, United States;1. Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar Street, New Haven, CT 06520-8042, United States of America;2. Department of Radiology, Brigham and Women''s Hospital, Harvard Medical School, Francis Street, Boston, MA 02115, United States of America;3. Department of Radiology, Columbia University Medical Center, Milstein 3rd Fl, New York NY 10032 United States;4. Department of Diagnostic Radiology, Yale School of Medicine, Box 208042, Tompkins East 2, 333 Cedar St, New Haven, CT 06520-8042, United States of America |
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| Abstract: | ObjectiveTo test the performance of free-breathing Dynamic Contrast-Enhanced MRI (DCE-MRI) using a radial volumetric interpolated breath-hold examination (VIBE) sequence combined with diffusion-weighted imaging (DWI) for quantitative solitary pulmonary nodule (SPN) assessment.MethodsA total of 67 SPN cases receiving routine MRI routine scans, DWI, and dynamic-enhanced MRI in our hospital from May 2017 to November 2018 were collected. These cases were divided into a malignant group and a benign group according to the characteristics of the SPNs. The quantitative DCE-MRI parameters (Ktrans, Kep, Ve) and apparent diffusion coefficient (ADC) values of the nodules were measured.ResultsThe Ktrans and Kep values in the malignant group were higher than those in the benign group, while the ADC values in the malignant group were lower than those in the benign group. Furthermore, the Ktrans value of adenocarcinoma was higher than that of squamous cell carcinoma and small cell carcinoma (P < 0.05). The Ve value was significantly different between non-small cell carcinoma and small cell carcinoma (P < 0.05). With an ADC value of 0.98 × 10−3 mm2/s as the threshold, the specificity and sensitivity to diagnose benign and malignant nodules was 90.6% and 80%, respectively.ConclusionHigh-temporal-resolution DCE-MRI using the r-VIBE technique in combination with DWI could contribute to pulmonary nodule analysis and possibly serve as a potential alternative to distinguish malignant from benign nodules as well as differentiate different types of malignancies. |
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