Syntheses of amphiphilic biodegradable copolymers of poly(ethyl ethylene phosphate) and poly(3-hydroxybutyrate) for drug delivery |
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Authors: | Jing Cheng Jun Wang |
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Institution: | (1) Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, 230026, China;(2) Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China |
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Abstract: | Biodegradable and amphiphilic triblock copolymers poly(ethyl ethylene phosphate)-poly(3-hydroxy-butyrate)-poly(ethyl ethylene
phosphate) (PEEP-b-PHB-b-PEEP) have been successfully synthesized through ring-opening polymerization. The structures are confirmed by gel permeation
chromatography and NMR analyses. Crystallization investigated by X-ray diffraction reveals that the block copolymer with higher
content of poly(ethyl ethylene phosphate) (PEEP) is more amorphous, showing decreased crystallizability. The obtained copolymers
self-assemble into biodegradable nanoparticles with a core-shell micellar structure in aqueous solution, verified by the probe-based
fluorescence measurements and transmission electronic microscopy (TEM) observation. The hydrophobic poly(3-hydroxybutyrate)
(PHB) block serves as the core of the micelles and the micelles are stabilized by the hydrophilic PEEP block. The size and
size distribution are related to the compositions of the copolymers. Paclitaxel (PTX) has been encapsulated into the micelles
as a model drug and a sustained drug release from the micelles is observed. MTT assay also demonstrates that the block copolymers
are biocompatible, rendering these copolymers attractive for drug delivery.
Supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No.20060358036) |
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Keywords: | poly(3-hydroxybutyrate) polyphosphoester drug delivery polymeric nanoparticles |
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