Coacervates as models of membraneless organelles |
| |
Institution: | Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, the Netherlands |
| |
Abstract: | Coacervates are condensed liquid-like droplets, usually formed with oppositely charged polymeric molecules. They have been studied extensively in colloid and interface science for their remarkable material properties. The liquid–liquid phase separation underlying coacervate formation also plays an important role in the formation of various membraneless organelles (MLOs) that are found in many living cells. Therefore, there is an increasing interest to use well-characterized coacervates as in vitro models that mimic specific aspects of MLOs. Here, we review five aspects – physical and chemical properties, hierarchical organization, uptake selectivity, formation dynamics, and maturation – that are of particular interest and discuss how useful coacervates are to better understand these aspects of MLOs. |
| |
Keywords: | Coacervates Membraneless organelle Liquid-liquid phase separation Multiphase Enzymatic control Active droplets Condensate |
本文献已被 ScienceDirect 等数据库收录! |
|