Recent advances in surface-active ionic liquid-assisted self-assembly systems for drug delivery |
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| Institution: | 1. Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan;2. Department of Chemistry, Jashore University of Science and Technology, Jashore, 7408, Bangladesh;3. Department of Chemical Engineering, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia;4. Advanced Transdermal Drug Delivery System Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan;5. Division of Biotechnology, Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan;1. Department of Chemistry, Islamic University of Science and Technology, IUST, Awantipora, Pulwama, J&K, India;2. Department of Chemistry, Jamia Millia Islamia, New Delhi, India;1. Salt and Marine Chemicals Division, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Gijubhai Badheka Marg, Bhavnagar 364002, Gujarat, India;2. Academy of Scientific and Innovative Research, Ghaziabad 201002, India;3. Department of Chemistry, Government Science College Pardi, Valsad 396125, Gujarat, India |
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| Abstract: | Surface-active ionic liquids (SAILs) are receiving growing interest as environmentally friendly designer surfactants for various applications, including drug formulation and delivery. The use of SAILs in the pharmaceutical industry has the potential to address the challenges associated with conventional surfactants. The tunable formation of complementary ion pairs from a diverse range of ions enables the task-specific optimization of SAILs. SAILs comprising second and third-generation cations and anions have been used to design biocompatible self-assembled systems including micelles, microemulsions, vesicles, liposomes, and nanoparticles for drug delivery carriers. Compared with conventional surfactant-based carriers, SAIL-based systems offer better pharmacokinetic and pharmacodynamic properties. This mini-review highlights recent findings on the formation of ionic liquid-based self-assembled systems and their potential applications in drug delivery. |
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| Keywords: | Surface-active ionic liquid Micelles Vesicles Microemulsion Drug delivery |
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