| 遗传算法与遗传编程的联用 |
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| 引用本文： | 周向东,李通化,边防,钱君律.遗传算法与遗传编程的联用[J].高等学校化学学报,2000,21(2):216-218. |
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| 作者姓名： | 周向东 李通化 边防 钱君律 |
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| 作者单位： | 同济大学化学系, 上海 200092 |
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| 基金项目： | 国家自然科学基金!(批准号 :29675013)资助 |
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| 摘 要： | 遗传算法 ( Genetic algorithm)是一种概率搜索算法 1] ,它的搜索过程与自然界生物进化过程相似2 ] ,在搜索过程中不易陷入局部最优 .遗传编程 ( Genetic programming)是近年来随着程序设计自动化而产生和发展起来的一种自动编程技术 3] .它继承了遗传算法的基本思想 ,是一种更广泛的适应系统方法 4 ] .本文将遗传算法和遗传编程相结合 ,构造了既有广泛的搜索能力 ,又有很强的局部精化能力的 GA- GP算法 ,充分利用了遗传算法局部精化能力强、遗传编程适应面广的优点 .该算法应用范围广 ,可应用于多种非线性函数式及分式关系的建模 .1…
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| 关 键 词： | 遗传算法 遗传编程 构效关系 |
| 收稿时间： | 1999-07-21 |
Application of Genetic Programming Coupling with Genetic Algorithm |
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| ZHOU Xiang-Dong,LI Tong-Hua,BIAN Fang,QIAN Jun-Lü.Application of Genetic Programming Coupling with Genetic Algorithm[J].Chemical Research In Chinese Universities,2000,21(2):216-218. |
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| Authors: | ZHOU Xiang-Dong LI Tong-Hua BIAN Fang QIAN Jun-Lü |
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| Institution: | Department of Chemistry, Tongji University, Shanghai 200092, China |
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| Abstract: | GA-GP is an algorithm for dealing with all kinds of nonlinear function relationships and fraction relationships, which use GP(Genetic programming) to create new individuals and GA(Genetic algorithm)to optimize them at the same time. In this way we make full advantage of GA and GP. We discuss the application of this algorithm in quantitative structure-activity relationships(QSAR) in the medicinal field. The result shows that GA-GP is better than ANN and mathematical expressions could be obtained. Expressions clearly express and explain QSAR of the medicine. All can show GA-GP has very wide applications in the medicinal field of the molecule design. |
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| Keywords: | Genetic algorithm Genetic programming QSAR |
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