Synthesis of several new lanthanide Glimepiride complexes for evaluation of microbial activity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of several new lanthanide Glimepiride complexes for evaluation of microbial activity

Authors:	M. G. Abd El-Wahed Samy M. El-Megharbel Mohamed Y. El-Sayed Yasmin M. Zahran Moamen S. Refat

Affiliation:	1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt 2. Department of Chemistry, Faculty of Science, Taif University, 888, Taif, Kingdom Saudi Arabia 3. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Port Said, Egypt

Abstract:	The complexation between lanthanide metal ions like Nd(III), Tb(III), and Er(III) with Glimepiride produces 1: 1 molar ratio (metal: Glimepiride) monodentate complexes of general formula: [M(GMP)(H₂O)₄]Cl₃·xH₂O, where: M = Nd, Tb, and Er, x = 1, 10, respectively. The structures of obtained compounds were assigned by IR, ¹H NMR and UV/Vis spectra. Themogravimetric analysis and kinetic thermodynamic parameters have proved the thermal stability of Glimepiride complexes. Obtained lanthanide complexes showed significant effect against some bacteria and fungi.

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