Alkaloids produced by endophytic fungi: a review |
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Authors: | Zhang Yanyan Han Ting Ming Qianliang Wu Lingshang Rahman Khalid Qin Luping |
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Institution: | Department of Pharmacognosy, Second Military Medical University, Shanghai 200433, P.R. China. |
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Abstract: | In recent years, a number of alkaloids have been discovered from endophytic fungi in plants, which exhibited excellent biological properties such as antimicrobial, insecticidal, cytotoxic, and anticancer activities. This review mainly deals with the research progress on endophytic fungi for producing bioactive alkaloids such as quinoline and isoquinoline, amines and amides, indole derivatives, pyridines, and quinazolines. The biological activities and action mechanisms of these alkaloids from endophytic fungi are also introduced. Furthermore, the relationships between alkaloid-producing endophytes and their host plants, as well as their potential applications in the future are discussed. |
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