Thermosensitive biodegradable polydepsipeptide |
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| Authors: | Ohya Yuichi Toyohara Megumi Sasakawa Mitsuhiro Arimura Hidetoshi Ouchi Tatsuro |
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| Affiliation: | Department of Applied Chemistry, Faculty of Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan. yohya@ipcku.kansai-u.ac.jp |
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| Abstract: | A poly(N-isopropylacrylamide) (PNIPAAm)-like biodegradable thermosensitive polydepsipeptide, poly[Glc-Asn(N-isopropyl)], was synthesized by introducing an isopropyl amide group into poly[Glc-Asn]. Poly[Glc-Asn(N-isopropyl)] was degraded in vitro by cleavage of the ester bonds in the main chain in water at room temperature. The non-toxic nature of the polymer and its degradation products, coupled with a cloud point at 29 degrees C in water, make this polymer attractive for biomedical implant applications. |
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| Keywords: | biodegradable injectable polymer polydepsipeptide polyesters thermosensitivity |
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