Determination of Diazepam and associated compounds in pharmaceutical preparations |
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| Authors: | J J Berzas G Castañeda M J Pinilla |
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| Institution: | Departamento de Química Analítica y Tecnología de Alimentos, Facultad de Químicas, Universidad de Castilla-La Mancha, E-13071 Ciudad Real, Spain e-mail: jjberzas@qata-cr.uclm.es, ES
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| Abstract: | A method for determining Diazepam and its associated compounds in pharmaceutical products by micellar electrokinetic chromatography (MEKC) is described. The separation was carried out at 30?°C and 25 kV, using a 25 mM borate buffer (pH 9.6) and 35 mM sodium dodecylsulfate (SDS) water solution. Under these conditions the analysis was carried out within 12 min with acceptable limits of detection and quantification. The method has been applied for quantifying Diazepam in different commercial formulations when it is the active drug and when it is employed associated with other drugs (Nortriptyline, Pyridoxine hydrochloride and Sulpiride). |
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