|
|||||
|
|
| Oxone/CaCl2/TEMPO体系在温和条件下对醇的氧化反应 | |
| 引用本文： | 陶晓春,余伟,张钧陶.Oxone/CaCl2/TEMPO体系在温和条件下对醇的氧化反应[J].有机化学,2010,30(2):250-253. |
| 作者姓名： | 陶晓春 余伟 张钧陶 |
| 作者单位： | (华东理工大学金属有机化学研究室 上海 200237) (SH-Icon, Inc., 118 Peace Avenue, Bolingbrook, IL 60490, USA) |
| 摘 要： | Oxone/TEMPO/CaCl2 (TEMPO＝2,2,6,6-Tetramethyl-1-piperidinyloxy)是一种稳定安全和易得的氧化催化体系, 在室温条件下, 可以氧化苄基或烷基醇生成醛或酮. 苄基伯醇很容易被氧化成相应的醛, 有较高的反应收率(90%～96%), 仲醇氧化成相应的酮, 收率在81%～85%之间, 1,4-丁二醇环氧化生成γ-丁内酯得到了94%的收率. |
| 关 键 词： | Oxone 醇 CaCl2 TEMPO 氧化 |
| 收稿时间： | 2009-05-15 |
| 修稿时间： | 2009-07-04 |
Oxidation of Alcohols under Mild Conditions Using Oxone/CaCl2/TEMPO |
|
| Institution: | (Laboratory of Organometallic Chemistry, East China University of Science and Technology, Shanghai 200237) (SH-Icon, Inc., 118 Peace Avenue, Bolingbrook, IL 60490, USA) |
| Abstract: | An efficient catalytic oxidization using a stable and safe oxone/CaCl2/TEMPO (TEMPO＝2,2,6,6-Tetramethyl-1-piperidinyloxy) system to convert alkyl or benzyl alcohols to carbonyl compounds under room temperature is described. Primary benzyl alcohols are readily oxidized to the corresponding aldehydes in excellent yields (90%～96%). Secondary alcohols are converted to corresponding ketones in 81%～85% yields. Oxidative cyclization of 1,4-diol to γ-lactone in 94% is obtained. |
| Keywords: | oxone alcohol calcium chloride TEMPO oxidation |
| 点击此处可从《有机化学》浏览原始摘要信息 | |
| 点击此处可从《有机化学》下载免费的PDF全文 | |