Synthesis and Crystal Structure of (Z)-Ethyl-4-(4-methoxy)benzylidene-2-(3,5-dimethoxypheny-tetrahydrofuran-3,3-dicarboxylate

The title compound (Z)-ethyl-4-(4-methoxy)benzylidene-2-(3,5-dimethoxyphenyl)-tetrahydrofuran-3,3-dicarboxylate has been synthesized,and its crystal structure was characterized by X-ray single-crystal diffraction.The crystal belongs to triclinie,space group P1,with a=8.140(3),b=11.966(4),c=13.771(5) Aα=67.366(4),β=85.165(5),γ=75.806(4)°,V=1200.1(7)A3,Z=2,C26H30O8,Mr=470.50,Dc=1.302 g/cm3,F(000)=500,λ(MoKa)=0.71073 A,μ=0.096 mm-1,R=0.0659 and wR=0.1841 for 3080 observed reflections (I > 2o(I)).As a keyintermediate of HIV-1 integrase inhibitor,the synthesis and structure confirmation of the title compound are important for further studies.