Convenient Synthesis of 3-(1-Carboxyalkyl)pyrido[2,3-d]pyrimidine-2,4-diones |
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| Authors: | M. Saoud F. B. Benabdelouahab F. El Guemmout A. Romerosa |
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| Affiliation: | (1) Fac. of Sciences-Tetouan, Univ. Abdelmalek Essaadi, B. P. 2121, Tetouan, Morroco;(2) Area de Quimica Inorganica, Facultad de Ciencias, Universidad de Almeria, 04071 Almeria, Spain |
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| Abstract: | A cheap and safe synthetic route to obtain 3-(1-carboxyalkyl)pyrido[2,3-d]pyrimidinediones (carboxyalkyl = -CHRCO2H; R = H; CH2; CH2Ph; Ph; CH2 (C3H3N2); (CH2)2CO2H; CH2CO2H) starting from 2,3-pyridinedicarboxylic acid is described. A process scheme consistent with empirical observations is proposed. |
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| Keywords: | amino acids pyrido[2,3-d]pyrimidine pyridinecarboxylic acids |
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