| pH荧光纳米传感器的研制及表征 |
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| 引用本文： | 梁建功,宋春华,何治柯. pH荧光纳米传感器的研制及表征[J]. 分析化学, 2005, 33(8): 1119-1121 |
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| 作者姓名： | 梁建功 宋春华 何治柯 |
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| 作者单位： | 武汉大学化学与分子科学学院,武汉,430072;武汉大学化学与分子科学学院,武汉,430072;武汉大学化学与分子科学学院,武汉,430072 |
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| 基金项目： | 国家自然科学基金;国家高技术研究发展计划(863计划) |
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| 摘 要： | 利用溶胶-凝胶技术制得了单分散性很好的二氧化硅纳米微球，通过共价偶联方式引入对pH变化敏感的荧光素异硫氰酸酯（FITC），这种FITC功能化二氧化硅纳米微球（FITC功能化硅微球）可作为pH荧光纳米传感器。当pH值从4.0变至7.5时，荧光强度增大约30倍。该传感器灵敏度高，响应速度快，容易制备，光稳定性好，可望用于单细胞的pH分析。
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| 关 键 词： | 二氧化硅微球 表面修饰 pH荧光纳米传感器 |
| 收稿时间： | 2004-07-14 |
| 修稿时间： | 2004-07-14 |
Development and Characterization of Novel Fluorescence pH Nanosensor |
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| Liang Jiangong,Song Chunhua,He Zhike. Development and Characterization of Novel Fluorescence pH Nanosensor[J]. Chinese Journal of Analytical Chemistry, 2005, 33(8): 1119-1121 |
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| Authors: | Liang Jiangong Song Chunhua He Zhike |
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| Abstract: | Mono-dispersed silicon dioxide spherical nanoparticles have been prepared by sol-gel method and a novel fluorescence pH nanosensor was developed with surface modification of fluorescein isothiocyanate (FITC). The nanosensor is sensitive over the pH range 4.07.5. When the pH value changes from 4.0 to 7.5, the fluorescence intensity of this nanosensor increases about 30 times. As a pH sensor, it has several (unique) advantages in high sensitivity, rapid response times, easy preparation and good photostability. It can (also) be further used as pH probe in single-cell analysis. |
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| Keywords: | Silicon dioxide microspheres surface modification fluorescence pH nanosensor |
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