Synthesis,antiinflammatory and antimicrobial activities of some 2,4-dichloro-5-fluorophenyl substituted arylidenetriazolothiazolidinones |
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Authors: | Mari S Karthikeyan Bantwal S Holla |
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Institution: | (1) Department of Chemistry, Mangalore University, Mangalagangothri, Karnataka, India |
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Abstract: | A series of 2,4-dichloro-5-fluorophenyl substituted arylidenetriazolothiazolidinones were obtained by one-pot reaction of
3-(2,4-dichloro-5-fluorophenyl)-4H-1,2,4-triazole-5-thiol with substituted benzaldehydes and monochloroacetic acid in the presence of acetic anhydride, acetic
acid, and sodium acetate. The structures of the newly synthesized compounds were characterized and confirmed by IR, 1H NMR, mass spectra, and elemental analysis. Compounds bearing the 4-methylthiophenyl, 3,4-methylenedioxyphenyl, and 2,3,5-trichlorophenyl
moiety showed excellent antiinflammatory activity. The antimicrobial screening studies revealed that compounds with 4-anisyl,
4-methylthiophenyl, 3,4-methylenedioxyphenyl, and 2,3,5-trichlorophenyl at position 5 of the arylidenetriazolothiazolidinone
moiety showed excellent activity against all tested strains at 6.25 μg cm−3 concentrations.
Correspondence: Mari Sithambaram Karthikeyan, Department of Chemistry, Mangalore University, Mangalagangothri 574199, Karnataka,
India. |
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Keywords: | 3-(2 4-Dichloro-5-fluorophenyl)-4H-1 2 4-triazole-5-thiol One-pot reaction Arylidenetriazolothiazolidinones Antiinflammatory Antimicrobial activity |
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