Highly selective acylation of ferrocene using microfluidic chip reactor

A rapid and highly selective acylation of ferrocene with various acid anhydrides using microfluidic chip as the reactor is described. The pressure driven glass microreactor was fabricated by standard photolithography and wet etching techniques. High conversions of ferrocene to the corresponding acylferrocenes were achieved at 25 °C and no diacylferrocene was observed in any case.