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A stereoselective synthesis of squalamine |
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| Authors: | Xiang-Dong Zhou Feng Cai Wei-Shan Zhou |
| Institution: | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China |
| Abstract: | Squalamine (1) was synthesized stereoselectively in 14 steps and 19% overall yield from 3-keto-5 -chenodeoxycholanate (2) by using a modified Sharpless asymmetric dihydroxylation as the key step. |
| Keywords: | squalamine improved Sharpless AD aminosterol stereoselective |
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