Biomimetic total synthesis of malbrancheamide and malbrancheamide B |
| |
Authors: | Miller Kenneth A Welch Timothy R Greshock Thomas J Ding Yousong Sherman David H Williams Robert M |
| |
Institution: | Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523-1872, USA. |
| |
Abstract: | The biomimetic total syntheses of both malbrancheamide and malbrancheamide B are reported. The synthesis of the two monochloro species enabled the structure of malbrancheamide B to be unambiguously assigned. The syntheses each feature an intramolecular Diels-Alder reaction of a 5-hydroxypyrazin-2(1H)-one to construct the bicyclo2.2.2]diazaoctane core, which has also been proposed as the biosynthetic route to these compounds. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|