| 盐酸美西律的两点滴定法和沉淀电位滴定法测定 |
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| 引用本文： | 高学鹏,陈红兰,陈水木,胡孝贵.盐酸美西律的两点滴定法和沉淀电位滴定法测定[J].化学研究,2010,21(6):60-62. |
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| 作者姓名： | 高学鹏 陈红兰 陈水木 胡孝贵 |
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| 作者单位： | 江西应用技术职业学院应化系,江西赣州341000 |
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| 摘 要： | 利用过滤和不过滤两种方式配制盐酸美西律试液,分别采用两点滴定法和沉淀电位滴定法测定了盐酸美西律片的含量.结果表明,基于两种测定方法的测定结果均处于《药典》规定的范围之内;与《药典》规定的紫外分光光度法测定结果相比,相对偏差均小于2%.而采用过滤方法配制试液的测定结果与采用不过滤方法配制试液的测定结果之间的偏差约为1%.
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| 关 键 词： | 盐酸美西律 两点滴定 沉淀电位滴定 测定 |
Determination of Mexiletine Hydrochloride by Double-point Titration and Precipitation Potentiometric Titration |
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| GAO Xue-peng,CHEN Hong-lan,CHEN Shui-mu,HU Xiao-gui.Determination of Mexiletine Hydrochloride by Double-point Titration and Precipitation Potentiometric Titration[J].Chemical Research,2010,21(6):60-62. |
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| Authors: | GAO Xue-peng CHEN Hong-lan CHEN Shui-mu HU Xiao-gui |
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| Institution: | (Department of Chemistry,Jiangxi College of Applied Technology,Ganzhou 341000,Jiangxi,China) |
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| Abstract: | Test solutions of mexiletine hydrochloride were prepared from the tablets by using filtration method and non-filtration method,respectively.The purity of mexiletine hydrochloride was determined by using double-point titration and traditional precipitation potentiometric titration,respectively.It was found that the analytical results based on the two kinds of titration methods were within the ranges specified in 《Pharmacopoeia》.Compared with the results of ultraviolet spectrophotometry prescribed in 《pharmacopoeia》,the results based on the two types of titration method showed a deviation of less than 2%.Besides,the deviation between the test solution prepared with filtration method and that prepared with non-filtration method was about 1%. |
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| Keywords: | mexiletine hydrochloride double-point titration precipitation potentiometric titration determination |
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